Kazi Ruhullah
Shahriar
ROS-Responsive Systems · Drug Delivery · Boronate Chemistry
Designing molecules that respond to disease — not just disease broadly, but the precise oxidative chemistry it produces. At the University of Tennessee, Knoxville, I build boronate-functionalized lipid systems that unlock drug release exactly where H₂O₂-rich microenvironments demand it.
Research Themes
Molecular design driven by biological relevance, validated through mechanistic rigor.
ROS-Responsive Lipid Systems for Controlled Release
Aryl boronate-functionalized lipids designed to respond selectively to H₂O₂ in oxidative disease microenvironments — enabling precision drug delivery in cancer and inflammation without off-target release.
Modular Synthetic Platform Development
Scalable synthetic routes for stimuli-responsive boronate molecules, built for structural tunability and reproducibility with pharmaceutical application in mind.
Fluorogenic & Mechanistic Assays
Integration of Nile Red fluorescence, dye-release kinetics, and biophysical analysis to connect molecular architecture with biological performance in liposomal formulations.